The Anatomy Of The Phrenic Nerve

Lynne Eldridge, MD

I am wondering if somehow I have Damaged My Phrenic Nerve?

The phrenic nerves not only have sensory and sympathetic functions, but have a very important function in being the only nerves that control the diaphragm, and hence, breathing. They are also relatively long nerves that travel through areas in the neck and chest that are subject to injury.

Fortunately, newer techniques such as diaphragmatic pacemakers and reconstruction are offering hope.

The two phrenic nerves are the only nerves that control the diaphragm, and thus have a critical role in breathing.

They also have sensory and sympathetic functions and are well known for being responsible for the referred pain to the shoulder that can accompany abdominal disorders.

Originating in the cervical spine (C3 to C5), they are vulnerable to injury as they travel down the neck and through the chest to insert in the diaphragm.

Damage to the nerves due to trauma, compression, some infections, and neuromuscular diseases can lead to partial or total paralysis of one or both sides of the diaphragm.

The phrenic nerves are also the nerves responsible for the hiccups, a very common symptom related to contraction and spasm of the diaphragm — .4

They are made up of axon fibers outside of the central nervous system, which convey information to and from the brain. Nervous tissue is one of the four types of tissue and is made up of neurons (nerve cells) and supporting cells called neuroglia. The neuroglia secrete a substance called myelin that lines the nerves and increases the rate of conduction (speed of nervous signal).

The phrenic nerves run from the cervical spine to the diaphragm bilaterally but are different in length. The left phrenic nerve is longer due to the course it takes as it descends.

The phrenic nerves begin in the neck (cervical spine) and travel to the right and left diaphragm to control contraction and inspiration.

The phrenic nerves originate primarily from the fourth cranial nerve but include contributions from both the third and fifth cranial nerve (C3-C5).

The phrenic nerves then insert into the left dome and right dome of the diaphragm respectively.

Known Anatomic Variations

In some people, an accessory phrenic nerve is present and may supply the subclavius muscle.

Let’s talk a bit about The Diaphragm

The diaphragm, often called the thoracic diaphragm, is a large muscle that separates the chest from the abdomen. This muscle plays an important role in breathing as its alternating movement helps you inhale and exhale.

ZEPHYR / SCIENCE PHOTO LIBRARY / Getty Images

It isn’t easy to recognize that you have a medical issue affecting your diaphragm. Symptoms, if present, can include issues like heartburn, nausea, and shortness of breath. Medical conditions involving the diaphragm can range from minor issues — such as hiccups — to more serious problems like hiatal hernias or paralysis.

Typically, problems with the diaphragm can be managed medically or treated with surgical intervention.

Function of The Phrenic Nerve

The phrenic nerve has sensory, motor, and sympathetic functions.

Motor Function

As the only nerves that control the diaphragm, the phrenic nerves have a vital role in respiration. Signals from the nerve (which can be voluntary or involuntary) cause the diaphragm to contract and flatten during inspiration, drawing air into the lungs. When the diaphragm relaxes, air is expelled.

Sensory Function

The phrenic nerves also transmit sensory information to the brain from the region of the central tendon of the diaphragm, the pericardium (the membrane lining the heart), and the outer lining (parietal pleura) that lies on the medial region of the lungs.

Pain detected by the phrenic nerves is often felt in another region (known as referred pain).

For example, irritation of the diaphragm (such as by carbon dioxide injected into the abdomen during laparoscopic surgery) may be felt as pain in the right shoulder.

Sympathetic Function

The phrenic nerves also appear to communicate with the sympathetic nervous system, but the significance of this is largely unknown. It has been noted that phrenic nerve stimulation for central sleep apnea can cause sympathetic activity that can lead to an increased risk of death.6

A 2018 study found that there are communicating fibers between the phrenic nerve and the sympathetic trunk and that the phrenico-abdominal branch of the right phrenic nerve is a branch of the celiac plexus. This finding could have important implications with regard to nerve stimulation practices.

Knowing what effect phrenic nerve stimulation has on sympathetic activity, and the results of that activity could help researchers and physicians better weigh the risks and benefits of these treatments.

Associated Conditions

Conditions associated with phrenic nerve function or dysfunction can range from benign hiccups to paralysis of both sides of the diaphragm and severe respiratory distress.

Hiccups

The phrenic nerve is responsible for the hiccup reflex.

For example, chronic hiccups can be related to conditions such as hepatitis, Crohn’s disease, and ulcers via sensory input to the phrenic nerve.

Chronic hiccups could also be potentially related to pressure on the phrenic nerve anywhere in its path from the neck to the diaphragm. For instance, a tumor in the mediastinum that presses on the nerve.

The importance of chronic hiccups, medically known as “persistent singuitis,” has gained renewed attention both for the severe quality of life issues they create and the importance of a thorough workup for potential causes.

While many different treatments have been tested, applying anesthesia to the phrenic nerve (one potential treatment) can give rise to another set of problems.

Paralysis of the Diaphragm

When one or both phrenic nerves are damaged or severed, the diaphragms can no longer contract, resulting in paresis (partial paralysis) or paralysis. This can be temporary or permanent depending on whether the nerve is only injured or if it is disrupted. When the nerve is disrupted, it does not recover.

There are a number of possible causes of phrenic nerve injury leading to paralysis of the diaphragm. These can be broken down by mechanism.

Trauma

The phrenic nerve(s) may be injured with spinal cord injuries, but this depends on the level of injury. Spinal cord injuries, especially above C5, often lead to paralysis of the diaphragm.

Surgery to the neck, chest, or liver can damage the nerve, and cardiac surgery is the most common cause of trauma to the phrenic nerve.3 When the inferior vena cava is clamped during liver transplantation, the nearby right phrenic nerve is often damaged.

In addition, trauma from motor vehicle accidents or falls and chiropractic manipulation can result in injury to the phrenic nerve.

Ablation for arrhythmias, or radio-frequency ablation for conditions such as atrial fibrillation, carries a risk for phrenic nerve injury. Repeated trauma to the neck (chronic cervical radiculopathy), anesthetic injury (the phrenic nerve may be damaged during an interscalene block for shoulder surgery), and birth trauma can all result in phrenic nerve injury.

Compression of the Nerve

Tumors or other structures that press on the phrenic nerve may lead to damage, including:

Neuromuscular Diseases

Paralysis of the diaphragm may occur with conditions such as:

Neuropathic, Autoimmune, and Infectious Processes

Conditions may include:

Idiopathic

It’s thought that in roughly 20% of cases, the cause of phrenic nerve palsy is unknown.

The symptoms of phrenic nerve injury depend on whether one or both nerves are damaged as well as the age of the person and other health conditions.

When only one nerve is damaged in an adult, there may be no symptoms, or there may be shortness of breath that is more apparent with exercise and problems with sleep-disordered breathing.

Symptoms are often more apparent in children who have weaker muscles and a more compliant chest.

When both nerves are damaged symptoms often include severe shortness of breath that is worse with lying down or when submerged in water up to the chest. Other symptoms may include chest wall pain, cough, fatigue, anxiety, and morning headache.

A significant decrease in lung capacity is noted whether a single or both nerves are damaged, with a decrease of roughly 50 percent due to one-sided injury and a decrease of 70 percent to 80 percent when both nerves are involved.

Diagnosis

The diagnosis is sometimes challenging as symptoms can mimic those of a number of heart and lung conditions. Since a paralyzed diaphragm results in a paradoxical motion of the diaphragm (the diaphragm moves up in the chest during inspiration and down during expiration), a person’s abdomen may be noted to move inward rather than outward with inspiration.

Elevation of the diaphragm on one side is often seen on a chest X-ray when one phrenic nerve is injured. The diagnosis is often made by visualizing the abnormal motion of the diaphragm on ultrasound or fluoroscopically. Pulmonary function tests will show a restrictive pattern (restrictive lung disease in contrast to obstructive).3

Treatment

The treatment of a phrenic nerve injury and paresis or paralysis of the diaphragm will depend on whether one or both nerves are involved, as well as whether the nerve is severed (as when it is disrupted during surgery) or remains functional (such as with ALS or a spinal cord injury).

For some people with unilateral phrenic nerve injury, no treatment is necessary. The accessory muscles of inspiration, such as the intercostal and abdominal muscles, provide some help.

With some injuries causing only partial paralysis, function may return in time. When both sides are involved or if one phrenic nerve is involved but a person is symptomatic, options include:3

It’s also important to treat the underlying cause of the phrenic nerve injury.

Prognosis

The prognosis of a phrenic nerve injury leading to paresis or paralysis of the diaphragm depends on the cause.3 With some infectious or autoimmune conditions, or when the nerve is only injured and not destroyed such as with radiofrequency ablation, function may be restored in several months.

Since nerves such as the phrenic nerve do not regenerate, complete disruption of the nerve will lead to permanent paralysis of the diaphragm.

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